BioSpec 70/30 and 94/30
Studies with intricate set-ups or on animals up to the size of rabbits can be conducted with the extremely physically stable, 30 cm bore size BioSpec 70/30 and BioSpec 94/30.
Wide bore
Strong magnet
Destaques
Highlights
30 cm
30 cm of space for largest gradients, PET insert, peripherals, and animals up to the size of rabbits
超盾冷藏
Helium zero-boil-off and Nitrogen free USR magnet technology for longer service intervals
Stability
Pulse tube cryo-cooler technology for the greatest physical stability essential for optimal artifact-free performance and the cleanest images
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- 零直升机um boil-off technology, nitrogen-free, Ultra Shielded and Refrigerated (USR) magnet technology for reduced maintenance costs and longer service intervals
- Accurate animal positioning with the motorized animal handling system for increased throughput
- Full second order and z3 high power shim channels guarantee optimal performance for spectroscopy and MRI
- Scalable AVANCE NEO electronics enabling both MRI and MRS applications and incorporating up to 16 receiver channels
- Real-time spectrometer control for optimization of acquisition parameters during scan
- High performance BGA-S-HP gradients with highest amplitudes and slew rates, shim strengths and duty cycles
- Fast and easily mountable gradient/shim inserts for optimum gradient/shim performance for small samples available
- Cold shipping for most cost and time effective installation
- CompleteRF coil portfoliofor mice and rats available, including coils for head, brain, cardiac, body, optogenetics, Arterial Spin Labeling, multi-channel array coils with up to 16 channels, and x-nuclei
- MRI CryoProbeswith 2 element, 4 element, or as 13C for mice as well as 4 element for rat delivering an exceptional increase in sensitivity
- In-house development and production of all key components (software, magnet, gradient, spectrometer, RF-coils) ensures the best performance and short repair times
Aplicações
Multiple Drug Resistance Bacteria Monitoring
Combination of 19F & 1H MRI performed on a BioSpec 70/30 for monitoring bacterial inflammation in thigh in antibiotic-resistant staphylococcus aureus treated mouse promises to be an effective tool to investigate the efficacy of therapeutic agents during acute and chronic phase of bacterial infection. Courtesy: T Hertlein, Institute for Molecular Infection Biology, Würzburg and V Sturm, P Jakob, University of Würzburg, Wurzburg, Germany Reference: T. Hertlein et al., PLoS One 6(3): e18246
肿瘤Microenvironment
In addition to the metabolic information provided by PET and the superior soft tissue contrast provided by MRI, multi-parametric PET/MR imaging allows even deeper insights, such as in this mouse glioma model study performed on a BioSpec 70/30 equipped with a PET insert, in which the FDG uptake showed heterogeneity in the tumor corresponding to regions with low diffusion suggesting loci of high cellular division (white arrow). Courtesy: U Himmelreich, W Gsell, C Casteels, M Riva, and C Deroose, KU Leuven, Leuven, Belgium
DTI in Non-Human Primate
Fractional Anisotropy (FA) maps of crab-eating macaques can easily be performed on a BioSpec 70/30 due to its large bore size. Courtesy: Wake Forest Baptist Medical Center, Winston-Salem, NC, USA
Functional Spectroscopic Imaging in Mouse Brain
Significant increase of glutamate and lactate observed in brain of mouse with 2 mA electrically stimulated hind paw recorded on a BioSpec 94/30 equipped with an MRI CryoProbe. Courtesy: A. Seuwen, M. Rudin, ETH Zurich, Zurich, Switzerland
In Vivo Mouse Brain Fiber Tracking
20 µm in plane resolution made possible with BioSpec 94/30 equipped with an MRI CryoProbe. Courtesy: V Zerbi, M Rudin, ETH Zurich, Zurich, Switzerland
Mass Extinction Event Drivers Identification
Ocean warming effects the cardiovascular system of scallops. This investigation was made possible using self-gated IntraGate FLASH on a BioSpec 94/30 even when the bivalve was placed within highly conductive sea water high conductive sea water. Courtesy: C. Bock, Alfred-Wegener-Institute Helmholtz Centre for Polar and Marine Research, Bremerhaven, Germany
Especificacoes
Magnet
| Field strength: | 7 Tesla (BioSpec 70/30), 9.4 T (BioSpec 94/30) |
| Bore diameter: | 30 cm |
| Homogeneity (180 mm DSV): | ± 10 ppm |
| Magnet technology | 零直升机um boil-off technology, nitrogen-free, Ultra Shielded and Refrigerated (USR) superconducting magnet for long hold-times, long maintenance intervals |
Gradients
| Gradient inner diameter: |
200 mm |
| Gradient strength: |
200 mT/m (300 mT/m with high power option) |
| Gradient insert with 1000 mT/m is available | |
| Slew rate: | 640 T/m/s (1040 T/m/s with high power option) |
| Actively shielded gradient system | |
| Integrated shim coils for optimal field homogeneity |
ParaVision
- Intuitive software package, for multi-dimensional MRI/MRS data acquisition, visualization, reconstruction, and analysis of MRI and/or PET/MR data
- Over 100 validated and ready to use in vivo protocols and scan programs for mice and rats
- MRI sequence portfolio of more than 1,000 sequence variations, including wireless cardiac imaging using navigator based IntraGate methods with cartesian or radial readout, as well as short echo time imaging, such as UTE and ZTE
- In-house development and production of all key components (software, magnet, gradient, spectrometer, RF-coils) ensures the best performance and short repair times
PET Insert or Inline
Upgradable with state-of-the-artPET module as inline or insertwith full field of view and accuracy offers real, homogeneous sub-millimetric volumetric PET resolution and quantification in all three axes, in the entire field of view. This is possible due continuous crystal detectors with SiPM technology and true depth of interaction 3D precision equivalent to 10+ layer pixelated crystal detectors.
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Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging
Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.
LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory