Improve the ability in drug discovery and development
Improve the ability in drug discovery and development
When a new drug discovery and development, from the start of the initial research into a complete product delivery, is a long, complex and expensive process.Will be a new drug to market may need 12 to 15 years of time, cost or more than $1 billion.
However, such as nuclear magnetic resonance (NMR) spectroscopy, powerful technology can be introduced a preliminary selection stage, so as to accurately identify the most noteworthy candidate drug development, and to determine the most likely to be successful, it could save a lot of time and resources.
Find cures for human diseases, new drugs from bacteria to cancer, nuclear magnetic resonance (NMR) depends on the continuous development of analytical techniques, etc.
Traditional lengthy process
The traditional drug discovery process begins with certain targets.Targets are usually a type of protein, such as the G protein coupled receptor (GPCR) or kinase.Clues to the second step is found, that is, to determine the potential candidate drugs (hit), which had the potential to treat small molecules or larger biological products (such as proteins or antibodies).
These precursor molecules must achieve drug targets and show the required activity.Here, the high-throughput screening (HTS) is usually used to determine the promising candidate precursor molecules (hit - to - lead).Hit the purpose of the pilot process is to produce more effective and more selective compounds, then carries on the optimization, to produce safe and effective drugs.
To speed up the process
Through experimental high-throughput screening (HTS) identify promising clue may spend a lot of time and cost.In order to play a role, each medicine must be applied to the correct target, and understand the targets of three dimensional (3 d) structure is referred to as drug design based on the structure of the basis for the rapid growth of drug research methods.
Researchers in drug discovery and development depends on a series of tools to identify and identification of new drugs.High performance liquid chromatography (HPLC), mass spectrometry (MS), capillary electrophoresis (CE) and vibration spectrum method (infrared and Raman) are used for high-throughput screening (HTS), but these methods can not provide the necessary research targets structures of these molecules and their details.
The advantage of nuclear magnetic resonance (NMR)
Nuclear magnetic resonance (NMR) spectrum can be integrated into the automation work process, to rapidly determine the strength of the combination of candidate drugs and target.By using nuclear magnetic resonance (NMR), research and development laboratory can screen tens of thousands of compound, observe the binding activity, and determine which targets need to verify, and taken it to lead discovery.
For example, nuclear magnetic resonance (NMR) has been identified as establishedGPCRsThe key method of knowledge.GPCRs是一个流行的蛋白质药物靶点家族，可调节几个重要的生理过程，包括细胞增殖、分化、神经传递和细胞死亡。核磁共振（NMR）能够研究与GPCRs和潜在候选药物之间相互作用有关的动态特征，以帮助确定哪些是最值得投入开发时间和资源的药物。
Characterization of new anti-cancer drugs
Cancer is the second leading cause of death in the world, one in every six people in all over the world people die of cancer.In 2018 alone, 9.6 million people die of cancer.
As the development of new, more effective treatment, cancer mortality rates have fallen, but in cancer development, which may lead to cancer resistant to existing treatments.Once the cancer resistance, it will continue to grow in a most uncontrolled fashion.
As a result, people have been looking for has a series of novel anticancer agent role model.For example, it was found that the development of tumor and angiogenesis closely related to the generation of new blood vessels in the (), so it become one of the key treatment goals.
Using nuclear magnetic resonance (NMR) spectroscopy, new research has identified the radix scutellariae, structural adjustment, the Chinese flowering plants dry scutellaria root extract has significant anti angiogenesis and anti-cancer effect, and no toxicity.
As we know, in order to find new potential drugs and develop it into a successful treatment, the researchers should not only rely on sophisticated technology, and rely on innovation instruments.Nuclear magnetic resonance (NMR) meet the requirement of the two, it provides a platform that will continue to enhance the ability of drug discovery and development in the future.