Nuclear magnetic resonance (NMR) technology processing spirit of active substances

As in many countries, since "Spice" was born in 2008, Germany had to deal with special drugs or the rise of new mental active substances (NPS).These drugs suppliers exploited a legal loophole, the new has not yet been identified by the authorities and listed in the list of compounds is not illegal.Although many of these compounds and the structure and effect of existing drugs are very similar, but this does not mean that they are illegal.NPS lead to adverse consequences could be very serious, including death.The fear is that because of their "legitimate" status, everyone thinks they are particularly attractive to inexperienced users.

Therefore, many countries such as Germany introduced new legislation designed to handle nuclear NPS, even though the authorities have not sure these material, also can be classified as illegal substances.Some countries, such as Britain and Ireland, adopted by the spirit of active role for material classification method.Countries such as Germany, Croatia and Turkey chose classified according to the structure characteristics of the material.

From Brunswick, researchers at the university of technology in a recent study (Ernst, 2019) characterized by the use of nuclear magnetic resonance (NMR) technology is common online drug purchase samples of a new type of NPS.

The team from four German shop 15 kinds of "class - the Spice" herbal mixture.Gas chromatography - mass spectrometry was found in samples from three independent active ingredients, two of them have known.However, 12 of the 15 samples contain a previously described compounds.They use, including nuclear magnetic resonance (NMR), a series of technology for this kind of material (5 f - Cumyl - PeGaClone) for further investigation.

Team used TCI three resonant inverse probe equipped brooke AVANCE nuclear magnetic resonance spectrometer analyzes the discovery of new compounds.Data showed that 5 f - Cumyl - PeGaClone close to describe Cumyl - PeGaClone before, and only minor structural differences.It is similar in structure and with 5 f - the ADB, and 5 f - the ADB has recently been listed in Germany's main method of narcotic drugs, and only appear in one of the 15 samples online.

However, 5 f - Cumyl - PeGaClone common structural elements and 5 f - the ADB has not been included in the special method of NPS, which means that new compounds distributors successfully exploited this vulnerability, that is to say, this kind of new compounds have not been covered by any law of the country.

, the researchers said the findings highlighted the health risks from NPS.

"As observed over the years, the consumers of these products is still very high health risks," the team wrote in the journal international forensic science.They point out, though different from in 2008 the original product, but at least one sample was labeled as the "flavor".

"This in turn increase the end user's health risks, which based on the experience of the previous expected effect and as a result of not understanding the unknown concentration of new active ingredient and any unforeseen effects."

They note that these samples contain a variety of different efficacy, ranging from 17 to 76 mg/G, and the user did not say this change on the package.However, there are signs that the problem of NPS is unlikely to disappear soon, these data also suggest that the distribution of such products business can be made, may even be harvested up to 42 times return on investment.

In short, nuclear magnetic resonance (NMR) is clear to identify and quantify the unknown substances (such as the emergence of new NPS) key method.According to brooke's vision, namely in the science center using console AVANCE NEO nuclear magnetic resonance spectrometer, the local laboratory using Fourier 80 desktop nuclear magnetic resonance spectrometer, realize the interconnection of forensic laboratories, so that law enforcement authorities to effectively against this threat.

On these two kinds of nuclear magnetic resonance spectrometer using the same brooke industry standard nuclear magnetic resonance (NMR) analysis software TopSpin ™, its remarkable synergistic effect for remote data exchange knowledge, experience, and opened the door.By using a configurable on brooke desktop spectrometer software interface button, the experts GO - SCAN, the application of nuclear magnetic resonance (NMR) technology has been further simplified.

This unique function creates a distributed lab topology structure, make nuclear magnetic resonance (NMR) detection can in any place, and fundamentally prevent the spread of NPS effectively.In this sense, brooke with leading global law enforcement agencies, by breaking the trend to protect the safety of the people.

• Halter S, Haschimi B, Mogler L, et al. The Impact of legislation on NPS markets in Germany - the rise and fall of 5 f - ADB. Drug Testing & Analysis, 2020;Doi: 10.1002 / dta. 2786.
• Boehmer Kraemer M, A, Madea B, et al. The Death cases involving certain new psychoactive substances: A review of the literature. The Forensic Science International, 2019;298:186-267. Doi: 10.1016 / j.f orsciint. 2019.02.021.
• Ernst L, Langer N, Bockelmann A, et al. Identification and quantification of synthetic cannabinoids in 'the spice - like herbal mixtures, the Update of the German situation in summer 2018. The Forensic Science International, 2019;294:96-102. Doi: 10.1016 / j.f orsciint. 2018.11.001.