Biological distribution

Understanding of drug candidates in (a) biological and predict its effective dose distribution of target organs, can help the pharmaceutical manufacturers to choose the best drug molecules and mode, and before the first human trials, or in the use of expensive clinical PET (positron emission computed tomography (ct) imaging) scan before, big development cost and time saving.Of target molecules by radioactive marker, not only can track the distribution of molecular biology, along with the change of time, can also clarify drug interaction with target.Essentially, whether need to detect molecules successfully reach the target, or whether the miss distance is cumulative, causing potential safety problems.

Brooke can provide the most advanced nuclear molecular imaging system.Such as Si78 PET equipment can partner brooke BioSpec MRI, as well as independent multi-modal PET/CT (Si78) and PET/SPECT/CT (Albira) system, at the same time or online monitoring of drug distribution and the monitoring of biological treatment of functions and effects.Use PET system to study the roles of biological distribution and drug targets the main advantage is that the technology has incomparable sensitivity (molecular concentration can be as low as pmol).In addition, because the technology need to replace a single isotope in the molecule to be tested, so it's not obvious influence on the molecular structure or function of.In other words, being tested has and the original drug molecules of PK/PD properties.This is especially important for small drug molecules.For such as large molecules such as proteins and antibodies to build body, can be used in local SPECT (single photon emission computed tomography (ct) imaging) conjugate gradient reconstruction technology.The importance of this technology is self-evident, but from the perspective of biological distribution and pharmacokinetics of macromolecular triage.