Lead discovery

Through the use of mass spectrometry, high flux screening (uHTS) can be applied to a variety of large compound libraries.UHTS can achieve high throughput of more than $100000 a day as a sample Xu Na, and high durability, consists of millions of material screening of compound libraries to complete (primary screening).Brooke RapifleX MPP is unique on the market at present, can be used for the primary screening of the mass spectrometer.

In this era dominated by calculation of drug development, the focus on the small and rich compound library screening method, is becoming more and more important.Mass spectrometry can provide high throughput and good data quality, and reduce redundant information.In addition, the high concentration screening applies to flux surface plasmon resonance (SPR) technology.Compared with the nuclear magnetic resonance (NMR), SPR technology can provide a wide range of orthogonal information at the same time, including specific/selectivity and affinity and kinetic rate constant, and so on.

The combination of low molecular weight compounds usually have lower affinity, therefore needs the highest sensitivity in these compounds screening.Brooke provides a series of advanced high sensitivity instrument, used to filter based on fragments, using SPR, NMR, mass spectrometry, X-ray crystallography and, of course, such as technology.Brooke provides a set of indispensable tools, can promote drug discovery based on fragment (FBDD).

RapifleX MPP solutions launched a major innovation in the near future, can provide greater flexibility, and support a variety of HTS subsequent applications.These applications need to monitor a large number of specific compounds:

High throughput synthesis filterCan with the fastest speed screening compounds in chemical synthesis, so it can be very effectively obtain unprecedented chemical reaction detection depth.

In addition, through the use of mass spectrometry,The tag combination experimentNow also can achieve the highest flux and specificity.