Organic molecules of cocrystallization partner molecular compounds

Usually in less than an hour, we in the single crystal X-ray diffraction (XRD) SC solution can achieve high quality 3 d structure analysis, including the determination of absolute structure.This makes SC - XRD a very quick and comprehensive method.However, a large number of small or high flexible organic molecules is still difficult to find successful crystallization method.Our new molecular partner kit provides a way to get the efficient cocrystallization, this to the chemist and crystal at the toolbox increased another powerful method.

• Molecular chaperone method is very fast, and easy to use
• For hours to get structure, rather than a few weeks
• Only need a small amount of analytes
• High quality crystal
• Screening experiment of 52 kinds of organic molecules

- 88% of the samples obtained diffraction quality crystal

- 77% of the sample to obtain high resolution X ray diffraction structure

• Molecular chaperone compounds with high stability
• Analytes with 100% occupancy rate in the structure to ensure the reliable determination of the absolute structure

Three different kinds of molecular chaperone for:

• 1 hc-positie - four base (2, 4-2 oxygen benzene) adamantane A30D250 (TEO) P/N
• 1 hc-positie - four base (2, 4 - dimethoxy phenyl) adamantane A30D251 (TDA) P/N
• 1 hc-positie - four base (2 - bromine - 4 - methoxy phenyl) adamantane A30D252 (TBro) P/N

In addition to molecular chaperone, each kit contains:

• 30 crystal bottle
• Storage guidelines for use of the memory stick
• reference

Crystal molecular partner can significantly increase the likelihood of success, and provides quick analysis of organic analytes three-dimensional absolute structure graph.

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• F. Krupp, m. i. Picher, w. Frey, b. Plietker, c. Richert,Determining the Relative Configuration of Propargyl Cyclopropanes by Co - CrystallizationSynlett 2021, 32, 350-353.
• M. e. Casco, f. Krupp, S., a. Schwenger, Gratz v. Damakoudi, c. w. Richert, Frey, l. Borchardt,Non - porous organic crystals and their interaction with guest molecules from the gas phaseAdsorption 2020, 26, 1323-1333.
• F. the Krupp, w. c. Frey, Richert,Absolute Configuration of Small Molecules by Co - Crystallization. Angew. Chem. 2020, 132, 16009-16013;Angew. Chem. Int. Ed., 2020, 59, 15875-15879.
• F. the Krupp, s. He, w. c. Frey, Richert,A crystalline ready - to - use the form of cyclopentadieneSynlett 2018, 29, 1707-1710.

• P. e. - Alexandre, a. Schwenger, w. c. Frey, Richert,High loading crystals of tetraaryladamantanes and the uptake and release of aromatic hydrocarbons from the gas phase. Chem. Eur. J., 2017, 23, 9018-9021.
• C. Richert, f. Krupp,Encapsulating organic crystals (EnOCs)Synlett 2017, 28, 1763-1766.
• A. Schwenger, w. c. Frey, Richert,Reagents with a crystalline coat. Angew. Chem. 2016, 128, 13910-13913;Angew. Chem. Int. Ed., 2016, 55, 13706-13709.
• A. Schwenger, w. c. Frey, Richert,Tetrakis (dimethoxyphenyl) adamantane (TDA) and its inclusion complexes in the crystalline state: A versatile carrier for small molecules. Chem. Eur. J. 2015, 21, 8781-8789.