Electron paramagnetic resonance (EPR) technique used in the pharmaceutical field

To ensure the safety of the correct dosage, and the patient's treatment of the validity of the drug needs to be clear.In the process of drug degradation, often free radicals and transition metals are involved, which is the main reason leading to the invalid drugs.By analyzing the EPR signal, we can identify, quantify and monitoring in drug degradation time behavior of free radicals.

Forced oxidation, also known as "stress tests", often in the process of drug development, used to predict the purity of the drug, the efficacy and safety of influence the stability of the drug product.Stress tests are often exposed to heat, light or by drugs chemical reagent, to understand drug degradation pathway, stability and validity, and determine its internal development stable formula and evaluate oxidation efficiency.

As drug regulations pharmaceutical factory of active pharmaceutical ingredients (API) of the chemical reactions involved in the production has a more thorough understanding, including identification of reactive intermediates.Therefore, in the process of drug development, show the specific characteristics of a surge of new molecules is extremely important, while the EPR reaction monitoring is the key step in the optimization of drug synthesis.

In addition, understanding the reaction mechanism also helps to save costs, access to quality of the final product.Involving the free radicals and transition metal chemistry is to achieve maximum output and minimize environmental impact.

For drug manufacturing, equipment and packaging and drug itself, to the appropriate surface disinfection is very important.The most commonly used sterilization processes include gamma rays or electron beam irradiation, dry heat and pressure sterilization.But this will produce free radicals, free radicals can lead to be irradiated material is degraded, and cause are sterilized product physical and chemical characteristics of the change.It also can be resolved through parts of the sterilization process and reduce the drug efficacy, and may even become a toxicological risk factors.

All contain drugs may impurities from active pharmaceutical ingredients, excipients, or both.They may be in the process of preparation, packaging and storing monk.These impurities will bring many adverse effects, including lower therapeutic effect, shorten the expiration date, and induced toxicity.Among them, usually comes from a by-product of organic impurities, intermediates or degradation in the process of free radicals, and inorganic impurities usually is a transition metal.To this, using high sensitive EPR technology, can detect the low PPB level of trace impurities.