IVDr lipoprotein module

Lipoprotein is carrying water insoluble in blood lipid of the supramolecular assembly.Lipoprotein also have apolipoprotein, which decided the structure and function.Apolipoprotein by monolayer amphiphilic composed of phospholipids and embedded with cholesterol, it formed the surface of the lipoprotein, lipid and water environment of the isolation.Inner core is mainly composed of triglycerides and esterification of cholesterol.

Under the background of cardiovascular risk assessment, the concentration of the specific in lipoprotein cholesterol and triglyceride category is more useful than they are at the total concentration in plasma.Have a strong indications that further detailed classification of lipoprotein can improve cardiovascular risk prediction.

Using the 1 h-nmr method, can extract the lipoprotein relevant information:

• Plasma and serum
• Main LDL and VLDL, IDL, high-density lipoprotein cholesterol (hdl-c) class
• VLDL sub-types to VLDL VLDL - 1-6 (respectively according to density increase and a decrease in size)
• Six LDL sub-types of LDL - 1 to LDL - 6
• Four kinds and high density lipoprotein HDL - 1 to HDL - 4

• Including human serum/plasma samples of the most common 41 kinds of metabolites (free metabolites, protein denaturation processing) and the concentration range
  
• Including the identity matrix detection, identification of EDTA plasma, heparin plasma, the serum
• In the analysis report, according to the chemical category for grouping metabolites: alcohols and their derivatives, amine and its derivatives, amino acid and its derivatives, carboxylic acid, essential nutrients, keto acid and its derivatives, sugar and its derivatives, sulfa, additives

• Than the overspeed centrifugal lower fees
  
• Much faster turnaround time - a few minutes compared to a few days
• Fully automated and run simple (for example) by the MTA
• The sensitivity and specificity and overspeed centrifugal equivalent
• Small sample size (500 edged up) - better patient compliance
• Direct the preparation of samples
• The samples have no direct contact with the equipment
• Spectra can be used in a variety of types of analysis

• 600 MHz IVDr platform
  
• Using plasma/serum Bruker SOP
• Must check reference samples (best) a day on a regular basis of absolute temperature, solvent peak suppression and quantitative
• Visit brooke data analysis server for automatic remote analysis (using a special FTP will measure spectrum transmission to brooke server, after return result report)