Brooke IVDr for newborn screening (B.I.Q uant UR ne)
Urine by nuclear magnetic resonance (NMR) is a combination of selective screening including metabolic defects and other markers of disease targeted analysis and the healthy newborn model of target classification.
The targeted screening can be detected according to the normal reference value all visible deviation of NMR whether known or unknown.Figure 1 shows with normal deviation of the logo.Reference model contains all the NMR spectra with quantile figure combination, shown as the ribbon on the NMR spectra.Model can be superimposed on the spectrum of new samples and test with the consistency of the models, namely all resonance will be suitable for the model definition of the envelope.
This test can automatically perform in univariate or multivariate way.Sample spectra show a case of cana WJH (Canavan) syndrome cases.In the expansion of the NMR spectrum, N - acetyl aspartic acid signal can be clearly seen.
As B.I.Q UANT - UR part of the panel, n-acetyl aspartate can be automatic identification and quantitative.And the data can also be in the same accuracy under the premise of the show previously unseen deviation.
The influence of the metadata
In addition, using normal model can study the influence of the metadata on the NMR spectrum.We can see from figure 2 day after the birth of NMR spectrometer, the influence of life and the evolution of early metabolic profile (figure 2).When will the new sample mapping to the track, basic can determine whether to follow the model of development for a baby.Obviously, the sample B is corresponding to the development of early baby.Sample A is very interesting, because it was the fifth day, but on the map to model belong to 1 and 2 days.This means that the baby might delay, it is recommended that further testing, because the retardation is likely to be the first sign of congenital defect, through the general biological markers is not able to show it.
Support data interpretation of genetic metabolic disease
Brooke IVDr genetic metabolic disease module
Brooke IVDr genetic metabolic disease module (B.I.I EM), only For research purposes (For research use only), by using the database Metagene automatically B.I.Q UANT - UR urine quantitative interpretation results of diagnosis provide valuable support.Health care professionals in newborn, child and adult genetic metabolic disease diagnosis and management of the use of the information.
B.I.Q UANT - UR nuclear magnetic quantitative data with Metagene dedicated to brooke version of an existing database, the database contains nearly 1000 kinds of disease and its differential diagnosis information, provides rich data support for clinical doctors diagnose.Can interactively add clinically relevant information to help sort of potential diagnosis.This method not only support for the diagnosis of inherited metabolic disease, also support research in the field of pediatrics.
Brooke promises to provide clients with unparalleled throughout the buying cycle, from the initial consultation to the evaluation, installation, and service life of the instrument, it is LabScape always adhere to the service concept.
LabScape Maintenance agreement (Maintenance Agreements), the optional services (On - site On - Demand) and laboratory improvement plan (Enhance Your Lab) modern Lab is dedicated to provide you with a new method of Maintenance and service.