Ascend GHz spectrometer

Over the years, high resolution NMR is limited to 23.5 tesla's magnetic field, the equivalent of 1.0 GHz proton resonance frequency.This limitation is by the physical properties of the metal temperature superconductor (LTS), set in 2009, Lyon in France, the center of the high field NMR Avance ® 1000 spectrometer for the first time reached this field.

First discovered in the 1980 s of the high temperature superconductor (HTS) for our opened the door to a higher field intensity under low temperature, but the ybco tape manufacturing technology and the great challenge of superconducting magnet technology makes the development of the high field is very difficult, until recently a breakthrough.

Brooke unique to 1.1 and 1.2 GHz NMR magnet using a new design of the hybrid magnets inside adopts advanced high temperature superconductor (HTS), external low-temperature superconductors (LTS).Ascend is 1.1 and 1.2 GHz stable standard cavity (54 mm) magnet, the magnetic field uniformity and stability is very good, as to meet the requirements of demanding high resolution NMR.1.2 GHz spectrometer can be equipped with different ultra-high field probe, including CryoProbes for liquid NMR and fast magic Angle spinning solid NMR probe.

Brooke has always been committed to developing advanced NMR solution, in order to promote function - structural biology research.New GHz level NMR technology for protein - to the structure of the ligand affinity and specificity of interaction between foundation for advanced study, including a better understanding of membrane protein structure characteristic, and process of the molecular mechanisms involved in protein folding and aggregation and so on.

1.2 GHz spectral resolution and sensitivity of nuclear magnetic resonance spectrometer, has led the team to a more in-depth study on protein, a better understanding of amyloid accumulation of initial steps as well as the function and structure of the Tau protein, which is often associated with alzheimer's disease.

In 2019, brooke in Memphis, Tennessee st. Jude 's children's research hospital successfully installed the world's first 1.1 GHz NMR spectrometer system.

St. Jude's children's research hospital structure biology department chairman Charalampos Kalodimos Dr Said: "we are happy to be able to receive the world's first 1.1 GHz NMR spectrometer, this will be our partner in molecular and protein kinase molecular dynamics mechanism research fields such as research is the most important tool.We want to brooke this impressive technology achievements to sincerely praise."

Soon after, in early 2020, brooke European nuclear research center at the university of Florence (CERM) launched the world's first 1.2 GHz NMR system.CERM is Europe's structural biology research infrastructure of the research center in Italy.

After successful installation, CERM Lucia Banci and Claudio Luchinat professor said: "our lab successfully installed the world's first 1.2 GHz NMR spectrometer, we're really excited about that.We look forward to the equipment is used for us to alzheimer's disease and Parkinson's disease and other neurodegenerative diseases, as well as related to cancer and virus protein structure and function of the related research.Now, we are actively develop SARS - CoV - 2 protein related research work, and we will soon be able to record a new crown viral proteins first 1.2 GHz nuclear magnetic resonance spectrum!"

In late 2020, brook at the Swiss federal institute of technology (ETH) in Zurich successfully launched the world's second 1.2 GHz NMR spectrometer.The 1.2 GHz spectrometer was the first configuration for solid state NMR spectrometer.

At that time, the ETH Beat Meier, Matthias Ernst and Alexander Barnes, the professor said: "we are very excited to be able to the world's first 1.2 GHz solid NMR spectrometer installed successfully in our laboratory.The spectrometer in just months before the delivery, installation and NMR magnet field work going very smoothly.The completion of tasks of installation marks our nearly a decade ago began to cooperate with brooke's peak.We are looking forward to start our first super-high solid NMR experiments.

ETH will use the 1.2 GHz NMR machine system, the development of new solid-state NMR techniques, and apply these techniques research of chemical materials and biological systems, including Parkinson's and alzheimer's disease and other diseases related to protein fiber.1.2 GHz spectrometer will also be used as a further improvement in structure in the cell biology research related to nuclear magnetic resonance (NMR) method of the platform, and studies of solid catalyst and functional materials for energy conversion and data storage, etc.