Nuclear magnetic resonance (NMR) technology power to cope with the new spirit of active substances (NPS)
As in many countries, since "Spice" in 2008, German design drugs or have to cope with the rise of new mental active substances (NPS).Supplier of this kind of drug use of a loophole in the law, namely the authorities have yet to be determined and listed in the illegal listing of new compounds for breaking the law.Although many of these drugs are linked to certain structure and function is very similar to existing drugs.The adverse consequences of NPS can be very serious, and even death.Worryingly, believed to be due to its "legal identity", they are particularly attractive to inexperienced users.
Therefore, Germany and many other countries have introduced new legislation that specifically deal with NPS, even though the authorities have not thoroughly to find out certain substances, still can be classified as illegal.Some countries, such as Britain and Ireland, have used the classification method of "nonself" according to the material of spiritual role.Countries such as Germany and Croatia and Turkey choice is classified according to the structure characteristics of the material.
From Brunswick, university of science and technology (such as Ernst, 2019), the researchers conducted a study using nuclear magnetic resonance (NMR) technology for online purchase of widespread in drug samples had been used to characterize the new description of the NPS.
The team from four German online store 15 "Spice" herbal mixture.By gas chromatography - mass spectrometry isolated from samples of three kinds of active ingredients, including two known.15 samples, however, there are 12 compounds containing has not previously been described.They use a series of techniques including NMR, on 5 f - isopropyl acetophenone this kind of material for further inquiry.
Team used TCI triple resonant inverse probe equipped brooke AVANCE nuclear magnetic resonance spectrometer to analyze new compounds.Data show that the 5 f - isopropyl acetophenone and was previously described closely related isopropyl acetophenone, only minor structural differences.It is similar in structure and with 5 f - the ADB, 5 f - the ADB has recently according to Germany's main narcotics method is used for classification, only appear in one of the 15 samples obtained from the Internet.
However, 5 f - isopropyl acetophenone and 5 f's structural elements of all the ADB has not been listed in the specific NPS law, which means that the dealer of new compounds are successfully exploited this vulnerability, that is to say in any legislation of the country has not yet cover the new compounds.
The findings, say the researchers highlighted the health risks brought by the NPS.
The research team in Forensic Science International journal (International court Science) wrote: "according to many years of observation, these products are still facing very high health risks."They point out, though with 2008 of the original product is different, but at least one sample was labeled as the "Spice".
"And under the unknown concentration of new active ingredient is a lack of vigilance, once again, has added to the end user health risks, based on past experience and unforeseen effect of expectations."
, they said these samples contain 17 to 76 mg/G of different efficacy, and products for the user is not listed on the package.However, there are signs that the problem of NPS is unlikely to disappear soon, the data also showed that the distribution of such products business profits, return on investment may be up to 42 times.
NMR is clear, therefore, to identify and quantify the unknown material is a key method, such as the emergence of new NPS.Brooke, based on the a umption that use of the center for science in the console AVANCE NEO NMR spectrometer and 80 local lab desktop FOURIER spectrometer, interconnected forensic laboratories can make law enforcement authorities to effectively combat the threat.Two types of NMR spectrometer can use brooke NMR analysis of industry standard software TopSpin ™, a remarkable synergistic effect for remote data, experience and knowledge exchange opens the door.By using configurable on brooke's desktop model GO - SCAN button, the expert software interface, the application of NMR is further broken down.This unique function to create a distributed laboratory topology structure, make the NMR is everywhere, so as to effectively combat farthest from the spread of the NPS.Brooke all over the world in this sense the main law enforcement agencies to break the trend of the spread of the NPS in order to protect the public.
References:
- Halter S, Haschimi B, Mogler L, et al. The Impact of legislation on NPS markets in Germany - the rise and fall of 5 f - ADB. Drug Testing & Analysis, 2020;Doi: 10.1002 / dta. 2786.
- Boehmer Kraemer M, A, Madea B, et al. The Death cases involving certain new psychoactive substances: A review of the literature. The Forensic Science International, 2019;298:186-267. Doi: 10.1016 / j.f orsciint. 2019.02.021.
- Ernst L, Langer N, Bockelmann A, et al. Identification and quantification of synthetic cannabinoids in 'the spice - like herbal mixtures, the Update of the German situation in summer 2018. The Forensic Science International, 2019;294:96-102. Doi: 10.1016 / j.f orsciint. 2018.11.001.
