Using the orthogonal method for rapid analysis narcotics
For law enforcement agencies around the world, to detect illegal drugs is a long game.Drug analysis the main difficulty is that need to accurately identify suspicious substances and reasonable quantitative analysis.Data must be solid and reliable, and can be submitted, used in legal proceedings.
Tested material is divided into two categories: known, typical illegal drugs (e.g., cocaine) is common and new material.By changing the chemical structure, the effectiveness of these new materials can not only imitate classic narcotics, also can to avoid detection.These drugs is known as the new spirit of active substances (NPS).Because the traditional methods are difficult to identify these substances, and these NPS have been evolved and is not controlled, so the method based on standard database often don't apply.
These new material emerge in endlessly, in May 2017, The birth of a peer-reviewed, non-commercial analysis Data sharing platform, The NPS Data Hub.The platform by the national institute of standards and technology (NIST), Germany's federal XingJingJu and the U.S. drug enforcement administration (DEA) joint operations, can provide data for law enforcement and has about 440 users.
Orthogonal method is used for the analysis of the NPS
Brooke can provide the most comprehensive analysis for forensic application related technology and a unique solutions.For the orthogonal method applied in the field of forensic, brooke is deserved only one-stop service platform.Nuclear magnetic resonance (NMR) and mass spectrometry (MS) are two commonly used and mature narcotics analysis method.Because these two methods is based on the principle of science, therefore, all roads lead to Rome, analyte to provide clear identification analysis.
The two technologies is usually as a complementary technology, is widely applied to analyze different aspects of a thing.They can also be for another, that is, the orthogonal method, through the use of the two based on the principle of different technologies, to analyze the same aspect of the problem.By orthogonal methods (such as MS and NMR) for identification and quantitative analysis, can largely avoid false positive and false negative results.And for the legal proceedings, the orthogonal method of data is very solid and reliable, therefore most countries are definitely legislation test should be carried out using orthogonal method.
Toxtyper mass spectrometry
Brooke can provide all relevant instruments, in order to realize the reliable characterization of NPS.Toxtyper is a user friendly ready-to-use LC - MSn solutions, dedicated to drug and toxicology screening, can be in 11 minutes to complete a single analysis.Data dependent MSn model, which can be opened, Toxtyper without positive and negative ions mode switch.With open spectrum library (the user can update spectral library) matching and identification of compounds.Toxtyper can also provide semi-quantitative results, including the use of automatic on-line SPE sample preparation this option.
This software is applicable to various types of samples and spectral library, such as CIF material, SAP library (can be measured in a single screening at the same time and half quantitative analysis).Not only that, but it can also be to analyze complex material, such as synthetic marijuana and screening for completely unknown substances.In addition, by using maxtrac this kind of tool, the technology also can connect to the external databases such as ChemSpider, CABI or Capcom, to better screening.Test report can be generated into PDF format and sent via email.
80 desktop nuclear magnetic resonance spectrometer and Fourier Fourier CrimeLab narcotics analysis module
NMR application range is very wide, including the forensic identification of the suspect material and quantitative analysis, as well as for food adulteration, chemical warfare agents (CWA), explosives and solid waste is analyzed.Brooke for more than 40 forensic institutions provided more than 80 sets of floor type NMR system.
Brooke benchtop NMR system launched in Europe in 2019.It took more than 60 years of experience of precipitation, brooke succeeded in NMR, design into a compact, cross decision, in the form of making this technology can be applied to more lab.
Desktop system don't need new infrastructure, can be installed on the fume hood or work bench.Fourier 80采用免制冷剂的永磁体设计，易于维护且拥有成本低廉。
Fourier CrimeLab is the latest version of Fourier benchtop NMR system of forensic version 80.It combines designed solely for forensic application of professional software tools and the working process, can let users in high and low field NMR system implementation method is unified, and also can use all TopSpin pulse libraries.
Because usually close cooperation between forensic laboratories, work together to create a new process and learn new ways, so compatibility is vital, especially considering the NPS in those who have not yet been included in the standard library.
A set of typical NMR workflow
NMR because its in the structure of known/unknown material identification, validation, identification and quantitative aspects is famous for its excellent performance.Even in a targeted approach, NMR still shines.NPS is usually with known molecular structure of similar but slightly different.The difference is in the NMR spectrum is often obvious.Using mass spectrometry associated orthogonal method, can more reliably to distinguish between the two.
All NMR workflow starts in the sample preparation.Sample preparation is very simple -- just in dozens of mg samples with 2 ml of non-toxic solvent such as water.
Using TopSpin on desktop and existing floor system, can make different international/domestic method of transformation between the working process more simple.GoScan workflow contains data processing.In this step by Fourier CrimeLab predefined, can set its own personalized program to finish.
, which can identify suspicious material should be collected by nuclear magnetic spectra with the internal database or and non-commercial Shared database (such as NPS - Datahub) match, or both.
NMR is a quantitative analysis of any of the mixture compounds, without using any reference to the compounds.As a result, the NMR can finish these tasks perfectly, especially in the case of NPS emerge in endlessly.
NMR advantage: pre-test without separation of the components, and can accelerate the whole process -- in a few minutes then can realize the whole process of sample preparation to obtain visual results.
conclusion
The emergence of NPS is the world's law enforcement has long been faced with serious problems.Related legal proceedings requires a solid and reliable method and accurate recognition and quantitative analysis of NPS.Orthogonal method is a ideal - using two kinds of technology, on the basis of the principle of different science to detect the same kind of material.This can avoid false positive and false negative results.
Brooke Toxtyper solution can be used for MS analysis and Fourier NMR systems and 80 Fourier CrimeLab can be used for NMR analysis.To combine the two technologies are orthogonal, can get one for NPS recognition and quantitative analysis of solid and reliable solutions.
