Quantitative analysis: solid form new desktop solution

In the pharmaceutical industry, about 80% of the active pharmaceutical ingredient (API) tend to more than one crystal form, and even some in the form of the amorphous.

Due to the change of the structure will affect the physical and chemical properties of molecules, polymorphism in the feasibility and safety of drugs pose a potential risk.Therefore, prove that the polymorphism of active pharmaceutical ingredients (API) purity from early drug development to production plays a key role.

Although there are several ways to analyze solid form in different ways, but there is no universal method to quantify and monitor different apis form.

At the symposium on Internet, brooke TD - NMR medicine application product manager Venita Dr Decker and application, industrial and clinical application of manager/development engineer Marcio - Fernando Cobo Dr Discussed the existing methods, and involves the solid nuclear magnetic resonance (NMR) spectral technology.How they emphasized the solid nuclear magnetic resonance (NMR) is used for quantitative pharmaceutical preparations in solid Form, with the recent launch of nuclear magnetic resonance (TD - NMR) time domain method, namely brooke new desktop solution minispec Form Check the comparison.

Seminar firstly introduces current around many apis used in the pharmaceutical preparations of polymorphism, and use of these compounds in early drug development and research and development of the challenges faced by scientists.All these problems can be found using the desktop TD - NMR solution, because it is a combination of nuclear magnetic resonance (NMR) analytical procedures, and easy to use.

After the brief introduction of the main principle of nuclear magnetic resonance (NMR), the speaker is also simple to explain the traditional nuclear magnetic resonance (NMR) and the key differences between TD - NMR.They discuss a very important key factor is that TD - NMR is an ideal instrument to quantitative solid form, the process is for measuring physical properties rather than tailor-made chemical information.

Dr Decker, then explains the TD - NMR can be used to distinguish between liquid, solid and solid-liquid mixture samples, and can be launched against the ratio of solid components in the mixed system, the absolute number or percentage relative quality.In order to understand the brook minispec Form Check how to quantify the solid shape, Dr Decker first introduces the basic principle of saturation recovery experiment, and then played a video of the real shape inspection measurement.

Dr Decker is still in the second section of the video shows the minispec Form the second key component of the Check, also is the Dynamic Center software.Introduced how to use the software in the video multifunctional folder "drag" as a result, in a few seconds for the user to run a simple analysis.

This webinar also showed minispec Form Check other key functions, including notable including minimal sample preparation and calibration, the small size of desktop system, without the use of refrigerant magnet and particularly notable automatic parameter optimization and analysis capabilities.However, these are only for the solid form quantitative provides the advantage of the tip of the iceberg, network conference also talked about many other advantages.

Minispec Form Check system can be applied to a wide range of pharmaceutical applications, from polymorphism screening to screening, drug loading and storing is a fine chemical, polymer industry scientists of tools and other preparations.